| 19:30 | Dinamo Bucuresti | vs | Liberec |
| 19:30 | Steaua Bucuresti | vs | St. Patricks |
| 20:00 | FC Twente Enschede | vs | FK Karabakh |
| 20:00 | FC Vaslui | vs | AEK Athens |
| 20:00 | Sivasspor | vs | Shakhtar Donetsk |
| 20:00 | Slavia Prague | vs | Red Star Belgrade |
| 20:15 | FK Sarajevo | vs | CFR Cluj |
| 20:15 | Partizan Belgrade | vs | Zilina |
| 20:30 | Brondby | vs | Hertha BSC |
| 20:30 | Lech Poznan | vs | Club Brugge |
| 20:30 | Sion | vs | Fenerbahce |
| 20:45 | Ajax Amsterdam | vs | Slovan Bratislava |
| 20:45 | Benfica | vs | Vorskla Poltava |
| 20:45 | Galatasaray | vs | Tallinna FC Levadia |
| 20:45 | Genoa | vs | OB Odense |
| 20:45 | Lazio | vs | Elfsborg |
| 20:45 | NK Maribor | vs | Sparta Prague |
| 20:45 | Racing Genk | vs | Lille |
| 21:00 | Dinamo Zagreb | vs | Hearts |
| 21:00 | Everton | vs | Olomouc |
| 21:00 | Fulham | vs | Amkar Perm |
| 21:00 | Stabaek | vs | Valencia |
| 21:00 | Werder Bremen | vs | Aktobe |
| 21:30 | Nacional | vs | Zenit St. Petersburg |
| 22:00 | Athletic Bilbao | vs | Tromso |
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Description :UEFA Europa League
Play-Offs-First leg
